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For the treatment of mild to fairly severe pain, the synthetic opioid painkiller tramadol is employed. Like all opioids, it acts by attaching to opioid receptors in the brain, but it also has other modes of action that help it relieve pain. Back, joint, and post-surgical pain are among the diseases for which tramadol is frequently recommended. The fact that tramadol stimulates opioid receptors in addition to raising brain levels of neurotransmitters like norepinephrine and serotonin may be one of its special features and explain why it has analgesic effects. Unlike other opioids, it acts through two different mechanisms.

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